Treponema denticola is a Gram-negative bacteria. T. denticola dwells in a complex and diverse microbial community within the oral cavity and is highly specialized to survive in this environment. T. denticola is associated with the incidence and severity of human periodontal disease.
Treponema Denticola is one of three bacteria that form the Red Complex, the other two being Porphyromonas gingivalis and Tannerella forsythia. Together they form the major virulent pathogens that cause chronic periodontitis.
Treponema Denticola is a potential etiological bacterial agent for oral cancer. Treponema Denticola bacteria can penetrate gingival tissues and circulate through blood vessels, with opportunity to invade the heart and cardiovascular epithelium in medium to large arteries – including aorta, coronary and carotid arteries., leading to atherosclerotic vascular disease. It has been recognised that there is an association between oral and intestinal cancer related deaths and chronic periodontitis.