Staphylococcus haemolyticus is a Gram-positive bacterium. It is part of the skin flora of humans, and its largest populations are usually found at the axillae, perineum, and inguinal areas. S. haemolyticus also colonizes primates and domestic animals. It is a well-known opportunistic pathogen, and is the second-most frequently isolated nosocomial infection. Infections can be localized or systemic, and are often associated with the insertion of medical devices.