Eastern equine encephalitis (EEE), commonly called Triple E or sleeping sickness (not to be confused with African trypanosomiasis), is a disease caused by a zoonotic mosquito vectored Togavirus that is present in North, Central, and South America, and the Caribbean.
Epizootics in horses have continued to occur regularly in the United States. It can also be identified in donkeys and zebras. Due to the rarity of the disease, its occurrence can cause economic impact in relation to the loss of horses and poultry.
In humans, although infrequent, diagnosing equine encephalitis is challenging because many of the symptoms are shared with other illnesses and patients can be asymptomatic.